Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway
| Autor: | Charles A. Greer, Helen B. Treloar, Elaine L. Shay |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Olfactory system
Tenascin Perlecan Models Biological Article Extracellular matrix Mice Pregnancy Laminin medicine Animals Glomerulus (olfaction) Extracellular Matrix Proteins biology Olfactory Pathways Immunohistochemistry Sensory neuron Olfactory bulb medicine.anatomical_structure Immunology biology.protein Female Neuroscience Heparan Sulfate Proteoglycans Developmental Biology |
| Zdroj: | Developmental Dynamics. 237:1837-1850 |
| ISSN: | 1097-0177 1058-8388 |
| DOI: | 10.1002/dvdy.21595 |
| Popis: | Olfactory sensory neuron (OSN) axons follow stereotypic spatio-temporal paths in the establishment of the olfactory pathway. Extracellular matrix (ECM) molecules are expressed early in the developing pathway and are proposed to have a role in its initial establishment. During later embryonic development, OSNs sort out and target specific glomeruli to form precise, complex topographic projections. We hypothesized that ECM cues may help to establish this complex topography. The aim of this study was to characterize expression of ECM molecules during the period of glomerulogenesis, when synaptic contacts are forming. We examined expression of laminin-1, perlecan, tenascin-C, and CSPGs and found a coordinated pattern of expression of these cues in the pathway. These appear to restrict axons to the pathway while promoting axon outgrowth within. Thus, ECM molecules are present in dynamic spatio-temporal positions to affect OSN axons as they navigate to the olfactory bulb and establish synapses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text