Quantitative (1)H magnetic resonance spectroscopy of myoglobin de- and reoxygenation in skeletal muscle: reproducibility and effects of location and disease
| Autor: | S Zwicky, Karin Bruegger, Iris Baumgartner, Roland Kreis, Michael Ith, Bruno Jung, C Skjelsvik, Chris Boesch |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy chemistry.chemical_compound Oxygen Consumption In vivo Medicine Humans Radiology Nuclear Medicine and imaging Muscle Skeletal Peripheral Vascular Diseases Reproducibility Leg business.industry Myoglobin Skeletal muscle Reproducibility of Results Signal Processing Computer-Assisted Oxygenation Middle Aged Peripheral medicine.anatomical_structure chemistry Case-Control Studies Female business Quantitative analysis (chemistry) Perfusion Biomedical engineering |
| Zdroj: | Magnetic resonance in medicine. 46(2) |
| ISSN: | 0740-3194 |
| Popis: | 1H-magnetic resonance spectroscopy ((1)H-MRS) of deoxymyoglobin (DMb) provides a means to noninvasively monitor the oxygenation state of human skeletal muscle in work and disease. As shown in this work, it also offers the opportunity to measure the absolute tissue content of DMb, the basic oxygen consumption of resting muscle, and the reperfusion characteristics after release of a pressure cuff. The methodology to determine these tissue properties simultaneously at two positions along the calf is presented. The obtained values are in agreement with invasive determinations. The reproducibility of the (1)H-MRS measurements is established for healthy controls and patients with peripheral arterial disease (PAD). A location dependence in axial direction, as well as differences between controls and patients are demonstrated for all parameters. The reoxygenation time in particular is expected to provide a means to quantitatively monitor therapies aimed at improving muscular perfusion in these patients. |
| Databáze: | OpenAIRE |
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