Study of predictive value of pediatric risk of mortality (PRISM) score in children with end stage liver disease and fulminant hepatic failure
| Autor: | Wafaa El-Akel, Nehal El-Koofy, Noha Adel Yassin, Mortada M. El-Shabrawi, Mona E. Fahmy, Hanaa M. El-Karaksy, Nabil A. Mohsen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Tertiary referral hospital Severity of Illness Index End Stage Liver Disease Severity assessment Fulminant hepatic failure Predictive Value of Tests Internal medicine medicine Risk of mortality Humans Child business.industry Mortality rate Infant End stage liver disease Hepatology Liver Failure Acute Predictive value Survival Analysis Surgery ROC Curve Child Preschool Pediatrics Perinatology and Child Health Female business Follow-Up Studies |
| Zdroj: | Indian journal of pediatrics. 78(3) |
| ISSN: | 0973-7693 |
| Popis: | To evaluate the use of the PRISM score as a predictor of outcome in patients with end stage liver disease (ESLD) and fulminant hepatic failure (FHF). The present study included 30 patients with ESLD and FHF, with ages ranging from 2 to 108 months, who were admitted to the Emergency room (ER) and the Pediatric Hepatology Unit at Cairo University Children’s Hospital (tertiary referral hospital) over a six-month-period from May through October 2008. Survivors were followed up for 6 months. Two other scores were also calculated, the PELD score and the Child-Pugh score. The outcome was defined as survivors and deceased. Deceased patients as compared with survivors were significantly younger (median age 7 vs. 24 months, p = 0.003). A ROC curve was constructed for the PRISM score, the predicted death rate (PDR) and the PELD score in the 30 patients. PRISM score was significantly associated with mortality (p = 0.04). The best cut off value was 9.5 (70.6% sensitive and 61% specific). PDR was also significantly associated with mortality (p = 0.011). The best cut off value for PDR was 5.95 (70.6% sensitive, 85% specific). On the other hand, the PELD score was not associated with mortality (p = 0.202). PRISM score can be applied with an adequate degree of accuracy for severity assessment and mortality prediction to pediatric patients with ESLD or FHF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink