Captopril enhances in vitro human lymphocyte thymidine incorporation
| Autor: | Laura M. Howard, Michael R. Simon, Roger M. Morrell, Joel V. Weinstock, Larry D. Roi |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Captopril Proline Lymphocyte Immunology Biology In Vitro Techniques Toxicology chemistry.chemical_compound Internal medicine medicine Concanavalin A Humans Pharmacology (medical) cardiovascular diseases Lymphocytes Phytohemagglutinins Pharmacology Dose-Response Relationship Drug Angiotensin-converting enzyme In vitro Enzyme assay medicine.anatomical_structure Endocrinology Mechanism of action chemistry Enzyme inhibitor biology.protein medicine.symptom Thymidine circulatory and respiratory physiology medicine.drug |
| Zdroj: | Agents and actions. 15(5-6) |
| ISSN: | 0065-4299 |
| Popis: | Angiotensin-converting enzyme activity is present in human sarcoid as well as murine schistosome granulomas. Inhibition of angiotensin-converting enzyme by captopril results in decreased granuloma size in animals. Since captopril is used clinically to treat hypertension, its effect on human lymphocyte thymidine incorporation was determined. It was found that 5 X 10(-5) M and 10(-4) M captopril enhances lymphocyte thymidine uptake induced by 25 micrograms/ml phytohaemagglutinin-P. This suggests that captopril can alter immunological reactivity in man and that angiotensin-converting enzyme may have an immunological function. |
| Databáze: | OpenAIRE |
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