Nuclear actin: The new normal
| Autor: | Primal de Lanerolle, Leonid A. Serebryannyy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
DNA Repair
Health Toxicology and Mutagenesis macromolecular substances Chromatin remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Transcription (biology) Genetics medicine Animals Humans Molecular Biology Actin 030304 developmental biology Cell Nucleus 0303 health sciences Chemistry DNA Damage Repair Actins Chromatin Cell biology Protein Transport New normal medicine.anatomical_structure Double stranded Nucleus 030217 neurology & neurosurgery DNA DNA Damage |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 821:111714 |
| ISSN: | 0027-5107 |
| Popis: | The presence of actin in the nucleus has historically been a highly contentious issue. It is now, however, well accepted that actin has physiologically important roles in the nucleus. In this Review, we describe the evolution of our thinking about actin in the nucleus starting with evidence supporting its involvement in transcription, chromatin remodeling and intranuclear movements. We also review the growing literature on the mechanisms that regulate the import and export of actin and how post-translational modifications of actin could regulate nuclear actin. We end with an extended discussion of the role of nuclear actin in the repair of DNA double stranded breaks. |
| Databáze: | OpenAIRE |
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