Survey: calculation of the characteristics of oral diffusion-controlled release dosage forms related to the drug
| Autor: | J. M. Vergnaud, I. D. Rosca |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Drug
media_common.quotation_subject Diffusion Administration Oral Pharmacology Models Biological Dosage form Medication Adherence Matrix (chemical analysis) Pharmacokinetics Oral administration In vivo Humans Medicine Pharmacology (medical) media_common Dosage Forms Models Statistical business.industry Controlled release Delayed-Action Preparations business Half-Life Biomedical engineering |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 35:29-39 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | Oral dosage forms with controlled release exhibit various advantages over their immediate release counterparts, but they must be built adequately by dispersing the drug through the well-defined polymer matrix. This study is concerned with diffusion-controlled dosage forms to resolve the problems that appear: in vitro tests generally used for determining the kinetics of drug release do not take into account the nature of the drug. On the contrary, the plasma drug profiles obtained through in vivo tests strongly depend on the nature of the drug, through their typical pharmacokinetic parameters. Moreover, the effect of the stirring rate is difficult to evaluate. Following the demand from the FDA concerned with the in vitro/in vivo correlation, a numerical model was built so as to evaluate the plasma drug profile obtained with any drug delivered from a diffusion-controlled release dosage form. The results are expressed by connecting the half-life times of the drugs obtained either with bolus injection or with the dosage forms, for various values of the parameters of interest: the diffusivity of the matrix polymer and the size of the dosage form. Thus, these diagrams make it possible to promptly determine the characteristics of the dosage forms able to give the desired plasma drug profile for any drug. Of course, for each drug being defined by its pharmacokinetic parameters, the polymer matrix should be selected as a function of its diffusivity. Finally, the evaluation of the plasma drug profile is of effective help to determine quantitatively the effect of the intervariability of the patients as well as the effect of the patient's noncompliance. |
| Databáze: | OpenAIRE |
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