Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats
| Autor: | Jacinto da Costa Silva-Neto, Geanne K.N. Santos, João Henrique Costa-Silva, Daniela Maria do Amaral Ferraz Navarro, Almir Gonçalves Wanderley, Alice Valença Araújo, Camila Luiz Gomes, Melissa B.L. Nery, Eduardo S. Gonçalves, Juliano R. da Silva |
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| Jazyk: | angličtina |
| Předmět: |
Oral treatment
Copaifera multijuga oil Reproductive toxicity Traditional medicine Offspring lcsh:RS1-441 Copaiba oil Histology Biology Pharmacology Copaiba Oil lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) Reproductive performance Oral administration Sex organ General Pharmacology Toxicology and Pharmaceutics Chronic treatment Behavioral parameters Copaifera multijuga |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 24, Iss 3, Pp 355-362 Revista Brasileira de Farmacognosia, Volume: 24, Issue: 3, Pages: 355-362, Published: JUN 2014 Revista Brasileira de Farmacognosia v.24 n.3 2014 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 24, Iss 3, Pp 355-362 (2014) |
| ISSN: | 0102-695X |
| DOI: | 10.1016/j.bjp.2014.07.014 |
| Popis: | Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes. However, there is no report regarding its effect on reproductive performance after used in repeated doses orally. The present study evaluated the effects of the oral administration of Copaiba oil (at doses of 200, 500 or 2500 mg/kg) or water (control) for eight weeks in male Wistar rats. Treated males mated untreated females, and parameters as fertility rates, absolute and relative mass of accessory sexual organs and histology and development of the offspring were evaluated. Chemical analysis revealed the presence of 22 components accounting for 99.11% of the Copaiba oil. The main compounds identified were sesquisterpenes. The reproductive toxicology results indicate that there was no difference between the treated groups compared with the control group in any of the parameters, suggesting that the oral treatment with C. multijuga oil for eight weeks does not affect reproductive performance of male Wistar rats. Keywords: Copaifera multijuga oil, Copaiba oil, Reproductive performance, Reproductive toxicity, Chronic treatment, Behavioral parameters |
| Databáze: | OpenAIRE |
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