Angiogenesis in the lung
| Autor: | Lindsey Eldridge, Elizabeth M. Wagner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Endothelium Physiology Angiogenesis medicine.medical_treatment Neovascularization Physiologic 03 medical and health sciences Pneumonectomy 0302 clinical medicine medicine.artery medicine Animals Humans Lung business.industry Reviews and Research Papers Endothelial stem cell 030104 developmental biology medicine.anatomical_structure Vasa vasorum Pulmonary artery Blood Vessels business Bronchial artery 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Physiology. 597:1023-1032 |
| ISSN: | 1469-7793 0022-3751 |
| Popis: | Both systemic (tracheal and bronchial) and pulmonary circulations perfuse the lung. However, documentation of angiogenesis of either is complicated by the presence of the other. Well‐documented angiogenesis of the systemic circulations have been identified in asthma, cystic fibrosis, chronic thromboembolism and primary carcinomas. Angiogenesis of the vasa vasorum, which are branches of bronchial arteries, is seen in the walls of large pulmonary vessels after a period of chronic hypoxia. Documentation of increased pulmonary capillaries has been shown in models of chronic hypoxia, after pneumonectomy and in some carcinomas. Although endothelial cell proliferation may occur as part of the repair process in several pulmonary diseases, it is separate from the unique establishment of new functional perfusing networks defined as angiogenesis. Identification of the mechanisms driving the expansion of new vascular beds in the adult needs further investigation. Yet the growth factors and molecular mechanisms of lung angiogenesis remain difficult to separate from underlying disease sequelae. [Image: see text] |
| Databáze: | OpenAIRE |
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