2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Autor:	Emmanuel Pinard, Gerhard Trube, Vincent Mutel, Rene Wyler, Anne Bourson, Marie-Paule Heitz, Alexander Alanine, Ramanjit Gill, Bernd Buettelmann
Rok vydání:	2003
Předmět:	Class (set theory) Pyridines Stereochemistry Clinical Biochemistry Pharmaceutical Science Pharmacology Receptors N-Methyl-D-Aspartate Biochemistry Chemical synthesis Mice Structure-Activity Relationship Seizures In vivo Drug Discovery Animals Selective receptor modulator Molecular Biology Dose-Response Relationship Drug Chemistry Organic Chemistry Glutamate receptor Antagonist General Medicine Muscarinic acetylcholine receptor M1 Hydrogen-Ion Concentration Subtype selective Isoquinolines In vitro Acoustic Stimulation Mice Inbred DBA Molecular Medicine NMDA receptor Excitatory Amino Acid Antagonists
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:829-832
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00007-6
Popis:	Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs alpha1 and M1 receptors) and active in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7979588a08d9376725550b28bf5910 https://doi.org/10.1016/s0960-894x(03)00007-6 Zobrazit plný text záznamu Full Text from ScienceDirect