Successful Sequential Treatment with Itraconazole and ALA-PDT for Cutaneous Granuloma by Candida albicans: A Case Report and Literature Review
| Autor: | Qing Cai, Jia Chen, Lianjuan Yang, Xiuli Wang, Hong Yang, Zhi-qin Gao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Antifungal Agents Itraconazole Veterinary (miscellaneous) medicine.medical_treatment 030106 microbiology Photodynamic therapy Applied Microbiology and Biotechnology Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Medical microbiology Drug Therapy Candida albicans Medicine Dermatomycoses Humans Granuloma Photosensitizing Agents biology business.industry Candidiasis Aminolevulinic Acid Middle Aged biology.organism_classification medicine.disease Dermatology Corpus albicans Treatment Outcome Photochemotherapy Histopathology business Phototoxicity Agronomy and Crop Science medicine.drug |
| Zdroj: | Mycopathologia. 183(5) |
| ISSN: | 1573-0832 |
| Popis: | Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues. The patient was treated with itraconazole for 1 month and two sessions of ALA-PDT. After 2 months of follow-up, the patient was cured and has not experienced any recurrence to date. ALA-PDT was well tolerated in this patient with little pain. In general, application of PDT in mycoses is safe and effective in most cases. ALA-PDT is a good choice for inactivation of C. albicans. |
| Databáze: | OpenAIRE |
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