Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
| Autor: | Tony Duan, Zhijuan Cao, Xiujuan Su, Yingying Yang, Yan Zhao, Jing Hua |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Pregnancy lcsh:RC648-665 Obstetrics business.industry thyroid dysfunction pregnancy complications Endocrinology Diabetes and Metabolism Medical record Research hypertensive disorders of pregnancy Retrospective cohort study Odds ratio hypothyroxinaemia medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology Placenta previa Gestational diabetes Endocrinology Internal Medicine medicine Euthyroid Risk factor business |
| Zdroj: | Endocrine Connections Endocrine Connections, Vol 8, Iss 4, Pp 435-441 (2019) |
| ISSN: | 2049-3614 |
| Popis: | Background The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia. Results A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13–20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38–5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07–12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50–2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39–2.12; OR = 1.16, 95% CI: 0.72–1.86), macrosomia (OR = 1.71, 95% CI: 0.95–3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86–2.15) and placenta previa (OR = 1.62, 95% CI: 0.39–7.37). Conclusion IMH could be a risk factor for hypertensive disorders of pregnancy. |
| Databáze: | OpenAIRE |
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