In vivo detoxification of lipopolysaccharide by antimicrobial peptides
| Autor: | Wenxu Zhang, Carsten Schmuck, Junchen Wu, Jiangcheng He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Lipopolysaccharide Antimicrobial peptides Biomedical Engineering Chemie Pharmaceutical Science Bioengineering medicine.disease_cause 01 natural sciences Microbiology Sepsis Cell wall 03 medical and health sciences chemistry.chemical_compound Mice medicine Animals Humans Amino Acid Sequence Pharmacology biology Dose-Response Relationship Drug 010405 organic chemistry Pseudomonas aeruginosa Septic shock Organic Chemistry Pathogenic bacteria medicine.disease biology.organism_classification 0104 chemical sciences 030104 developmental biology chemistry Biochemistry A549 Cells Bacteria Biotechnology Antimicrobial Cationic Peptides |
| Popis: | Abundant lipopolysaccharide (LPS) can result in sepsis and septic shock, indicating a serious Gram-negative bacterial contamination. We have developed a novel strategy based on dendritic antimicrobial peptides that can detoxify LPS. The dendritic antimicrobial peptides bind to LPS at the surface of Gram-negative bacteria, killing the bacteria but removing the LPS from the cell wall of dead Gram-negative bacteria, hence detoxifying pathogenic bacteria in its host cells and effectively improving survival of animals infected with Pseudomonas aeruginosa. Our findings provide a way to detoxify bacterial contamination. |
| Databáze: | OpenAIRE |
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