Enantioselective desymmetrization of FTY720
| Autor: | Yuusaku Yokoyama, Maiko Hamada, Yuka Uchida, Isao Azumaya, Hidemasa Hikawa, Shoko Kikkawa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Chemistry
Fingolimod Hydrochloride Acylation Enantioselective synthesis Stereoisomerism General Chemistry General Medicine Desymmetrization Benzoates Catalysis chemistry.chemical_compound Benzoyl chloride Coordination Complexes Propylene Glycols Sphingosine Yield (chemistry) Drug Discovery Solvents Organic chemistry Oxazoles Copper |
| Zdroj: | Chemicalpharmaceutical bulletin. 62(10) |
| ISSN: | 1347-5223 |
| Popis: | A method for enantioselective desymmetrization of N-Ac and N-Boc-FTY720 by nonenzymatic asymmetric acylation was developed. Effective enantioselective monobenzoylation using benzoyl chloride in the presence of the tetraphenylbisoxazoline (L2)-CuCl2 complex gave the desired products 3a and 3b in 52-62% yield with 64% ee. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|