1H-NMR Urinary Metabolic Profile, A Promising Tool for the Management of Infants with Human Cytomegalovirus-Infection
| Autor: | Marta Nicolás-López, Marina Fenoy-Alejandre, Asunción de la Fuente-Juárez, Ignasi Barba, Pere Soler-Palacín, Marie Antoinette Frick, Paula López-López, Juliana Esperalba Esquerra, Maria Gemma Codina-Grau, Ángeles Linde-Sillo, Paula Rodríguez-Molino, Fernando Baquero-Artigao, Antoni Noguera-Julian |
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| Přispěvatelé: | Institut Català de la Salut, [Frick MA, Soler-Palacín P] Malalties infeccioses i immunologia pediàtrica, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Red de Investigación Translacional en Infectología Pediátrica (RITIP), 28046 Madrid, Spain. [Barba I] Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain. [Fenoy-Alejandre M] Malalties Infeccioses i Immunologia Pediàtrica, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [López-López P] Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Baquero-Artigao F] Red de Investigación Translacional en Infectología Pediátrica (RITIP), 28046 Madrid, Spain. Pediatrics Infectious Diseases Unit, Pediatrics Department, Hospital University La Paz, 28046 Madrid. [Rodríguez-Molino P] Pediatrics Infectious Diseases Unit, Pediatrics Department, Hospital University La Paz, 28046 Madrid. [Codina-Grau MG, Esperalba Esquerra J] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Linde-Sillo Á] Servei de Neonatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Human cytomegalovirus medicine.medical_specialty Infeccions per citomegalovirus pediatrics Endocrinology Diabetes and Metabolism Urinary system Physiology Other subheadings::Other subheadings::/congenital [Other subheadings] Urine Pediatrics Biochemistry Article 03 medical and health sciences 0302 clinical medicine Metabolomics 030225 pediatrics Acute care medicine Metabolome Molecular Biology Cytomegalovirus infections Pediatria Otros calificadores::Otros calificadores::/congénito [Otros calificadores] business.industry 1H-NMR metabolic profiling personas::Grupos de Edad::lactante::recién nacido [DENOMINACIONES DE GRUPOS] Gestational age Persons::Age Groups::Infant::Infant Newborn [NAMED GROUPS] medicine.disease metabolomics virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus [ENFERMEDADES] congenital infection 030104 developmental biology Metabolòmica human cytomegalovirus Nodrissons Malalties congènites Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections [DISEASES] business Metabolic profile |
| Zdroj: | Scientia Metabolites Dipòsit Digital de la UB Universidad de Barcelona r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Volume 9 Issue 12 |
| ISSN: | 2218-1989 |
| DOI: | 10.3390/metabo9120288 |
| Popis: | Congenital human cytomegalovirus (HCMV) infection is the most common mother-to-child transmitted infection in the developed world. Certain aspects of its management remain a challenge. Urinary metabolic profiling is a promising tool for use in pediatric conditions. The aim of this study was to investigate the urinary metabolic profile in HCMV-infected infants and controls during acute care hospitalization. Urine samples were collected from 53 patients at five hospitals participating in the Spanish congenital HCMV registry. Thirty-one cases of HCMV infection and 22 uninfected controls were included. Proton nuclear magnetic resonance (1H-NMR) spectra were obtained using NOESYPR1D pulse sequence. The dataset underwent orthogonal projection on latent structures discriminant analysis to identify candidate variables affecting the urinary metabolome: HCMV infection, type of infection, sex, chronological age, gestational age, type of delivery, twins, and diet. Statistically significant discriminative models were obtained only for HCMV infection (p = 0.03) and chronological age (p < 0.01). No significant differences in the metabolomic profile were found between congenital and postnatal HCMV infection. When the HCMV-infected group was analyzed according to chronological age, a statistically significant model was obtained only in the neonatal group (p = 0.01), with the differentiating metabolites being betaine, glycine, alanine, and dimethylamine. Despite the considerable variation in urinary metabolic profiles in a real-life setting, clinical application of metabolomics to the study of HCMV infection seems feasible. |
| Databáze: | OpenAIRE |
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