Notch signaling and new therapeutic options in liver disease
| Autor: | Carola M. Morell, Mario Strazzabosco |
|---|---|
| Přispěvatelé: | Morell, C, Strazzabosco, M |
| Rok vydání: | 2014 |
| Předmět: |
Notch inhibitors
Notch-2 intracellular domain Hey1 HSC cytokeratin-7 Notch intracellular domain RBP-Jκ Translational Research Biomedical cytokeratin-19 Liver disease 0302 clinical medicine Notch-1 intracellular domain MED/12 - GASTROENTEROLOGIA hepatic progenitor cell HCC HES1 IHBD Notch signaling hepatic stellate cell CCL4 Jagged-1 0303 health sciences Notch inhibitor Receptors Notch Hairy enhancer of split-related with YRPW motif1 Liver Diseases Liver Neoplasms hepatocellular carcinoma Alagille syndrome K19 N1ICD Liver regeneration Liver Hes3 signaling axis 030220 oncology & carcinogenesis HPC Recombination Signal Binding Protein Immunoglobulin Kappa J Stem cell cholangiocarcinoma MAML1 T-ALL Liver cancer Dll Sox9 Signal Transduction Liver repair Adult cancer stem cell T-cell acute lymphoblastic leukaemia Jag-1 Notch signaling pathway Sex determining region Y-box 9 Context (language use) Biology N2ICD Models Biological CSC GSI K7 03 medical and health sciences NICD Cancer stem cell Hairy enhancer of split-1 medicine gamma-secretase inhibitor Animals Humans Mastermind-like 1 CCA monoclonal antibodie intrahepatic bile duct 030304 developmental biology mAb AGS HNF1b Hepatology Hepatocyte nuclear factor 1β medicine.disease Liver Regeneration Hes1 Immunology Delta-like Cancer research carbon tetrachloride |
| Zdroj: | Journal of Hepatology. 60:885-890 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2013.11.028 |
| Popis: | SummaryNotch signaling is a crucial determinant of cell fate decision during development and disease in several organs. Notch effects are strictly dependent on the cellular context in which it is activated. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis. Recent advances have shed light on Notch as a critical player in liver regeneration and repair, as well as in liver metabolism and inflammation and cancer. Notch signaling is finely regulated at several levels. The complexity of the pathway provides several possible targets for development of therapeutic agents able to inhibit Notch. Recent reports have shown that persistent activation of Notch signaling is associated with liver malignancies, particularly hepatocellular with stem cell features and cholangiocarcinoma. These novel findings suggest that interfering with the aberrant activation of the Notch pathway may have therapeutic relevance. However, further studies are needed to clarify the mechanisms regulating physiologic and pathologic Notch activation in the adult liver, to better understand the mechanistic role(s) of Notch in liver diseases and to develop safe and specific therapeutic agents. |
| Databáze: | OpenAIRE |
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