CT angiography with cardiac MRI: non-invasive functional and anatomical assessment for the etiology in newly diagnosed heart failure
| Autor: | Richard Slaughter, Darren L. Walters, O. Christopher Raffel, Italo Porto, W. Strugnell, Christian Hamilton-Craig |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Ischemia Coronary Artery Disease Coronary Angiography Revascularization Risk Assessment Sensitivity and Specificity Severity of Illness Index Coronary artery disease Ventricular Dysfunction Left Predictive Value of Tests Risk Factors Cardiac magnetic resonance imaging Internal medicine Multidetector Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies cardiovascular diseases Cardiac imaging Aged Ejection fraction medicine.diagnostic_test business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Echocardiography Heart failure Angiography cardiovascular system Cardiology Female Queensland Radiology Cardiology and Cardiovascular Medicine business Heart Failure Systolic |
| Zdroj: | The International Journal of Cardiovascular Imaging. 28:1111-1122 |
| ISSN: | 1573-0743 1569-5794 |
| DOI: | 10.1007/s10554-011-9926-y |
| Popis: | Exclusion of ischemia is important in patients with newly diagnosed systolic heart failure (HF). We prospectively compared standard-of-care invasive catheter angiography (iCA) and echocardiography to a novel non-invasive strategy of both Coronary Computed Tomographic Angiography (CCTA) and Cardiovascular MRI (CMR) to determine the etiology of myocardial dysfunction Prospective data were collected from consecutive patients referred for iCA to investigate echocardiographically-confirmed new onset HF. CMR (1.5T GE) and dual source CCTA were performed within 2-7 days of iCA. Results were blinded and separately analyzed by expert readers. 426 coronary segments from 28 prospectively enrolled patients were analyzed by CCTA and quantitative iCA. The per-patient sensitivity and specificity of CCTA was 100% and 90%, respectively, negative predictive value (NPV) 100%, positive predictive value (PPV) 78%. Mean ejection fraction by CMR was 24%. Presence of ischemic-type LGE on CMR conferred a 67% sensitivity, 100% specificity, 90% NPV and 100% PPV. Combining CCTA with CMR conferred 100% specificity, 100% sensitivity, 100% PPV and 100% NPV for detection or exclusion of coronary disease. In patients with negative CCTA all invasive angiograms could have been avoided. In addition, two patients with no ischemic LGE by CMR had severe coronary disease on both CCTA and iCA, indicating global hibernation. This is a noteworthy finding in contrast to previous reports which suggested that absence of LGE rules out significant CAD. CCTA with CMR in newly-diagnosed HF enables non-invasive assessment of coronary artery disease, the severity and etiology of myocardial dysfunction and defines suitability for revascularization. Absence of ischemic-type LGE at CMR does not exclude CAD as a cause of LV dysfunction. A first-line strategy of functional and anatomic imaging with CMR and CCTA appears appropriate in newly diagnosed HF. |
| Databáze: | OpenAIRE |
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