Fractionated stereotactic radiation therapy for brain metastases: a systematic review with tumour control probability modelling
| Autor: | Patrick Lasala, Nitin Ohri, Wolfgang A. Tomé, Madhur Garg, Shalom Kalnicki, Sujith Baliga, J.L. Fox, Mary R. Welch |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_treatment
Treatment outcome Stereotactic radiation therapy Kaplan-Meier Estimate Radiosurgery Effective dose (radiation) Actuarial survival Stereotactic radiotherapy 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Probability Proportional Hazards Models Models Statistical Full Paper business.industry Proportional hazards model Brain Neoplasms Dose fractionation General Medicine Treatment Outcome 030220 oncology & carcinogenesis Dose Fractionation Radiation Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | The British journal of radiology. 90(1070) |
| ISSN: | 1748-880X |
| Popis: | Fractionated stereotactic radiotherapy (FSRT) is a relatively new option for the treatment of brain metastases. We performed a quantitative systematic review to determine if local control (LC) following is affected by FSRT dosing regimen.We reviewed articles describing LC following FSRT for brain metastases. LC data from each study were extracted from actuarial survival curves and aggregated to form a single data set. LC curves were generated using the Kaplan-Meier method. Log-rank testing and Cox proportional hazards modelling were utilized to test for associations between the biologically effective dose (BED) and LC. Tumour control probability modelling was performed to illustrate the relationship between the BED and the likelihood of LC after FSRT.10 studies (720 metastases) met inclusion criteria. Prescription doses ranged from 18 to 42 Gy, delivered in 3-12 fractions (BED range: 29-100 GyFSRT provides high rates of LC for patients with brain metastases. We found evidence for a dose-response relationship that should be explored in prospective trials. Advances in knowledge: This review identified a dose-response relationship for LC in patients treated with FSRT for brain metastases. |
| Databáze: | OpenAIRE |
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