Titanium Scaffolds by Direct Ink Writing: Fabrication and Functionalization to Guide Osteoblast Behavior
| Autor: | Daniel Rodríguez, José María Manero, Giuseppe Scionti, Diego Torres, Jordi Guillem-Marti, Elia Vidal, Elisa Rupérez, Maria-Pau Ginebra |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials, Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits, Institut de Bioenginyeria de Catalunya |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:TN1-997
Recombinant protein Materials science Titanium scaffold Biocompatibility 0206 medical engineering chemistry.chemical_element Thermoresponsive binder 02 engineering and technology Enginyeria dels materials [Àrees temàtiques de la UPC] Bone cements Osseointegration medicine General Materials Science thermoresponsive binder titanium Titani -- Aliatges Composite material Porosity direct ink writing lcsh:Mining engineering. Metallurgy Titanium Implants artificials Metals and Alloys technology industry and agriculture Implants Artificial osseointegration Adhesion Stress shielding 021001 nanoscience & nanotechnology equipment and supplies 020601 biomedical engineering titanium scaffold medicine.anatomical_structure chemistry Ciments ossis Surface modification Direct ink writing 0210 nano-technology Cancellous bone recombinant protein |
| Zdroj: | Metals, Vol 10, Iss 1156, p 1156 (2020) UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Metals Volume 10 Issue 9 |
| ISSN: | 2075-4701 |
| Popis: | Titanium (Ti) and Ti alloys have been used for decades for bone prostheses due to its mechanical reliability and good biocompatibility. However, the high stiffness of Ti implants and the lack of bioactivity are pending issues that should be improved to minimize implant failure. The stress shielding effect, a result of the stiffness mismatch between titanium and bone, can be reduced by introducing a tailored structural porosity in the implant. In this work, porous titanium structures were produced by direct ink writing (DIW), using a new Ti ink formulation containing a thermosensitive hydrogel. A thermal treatment was optimized to ensure the complete elimination of the binder before the sintering process, in order to avoid contamination of the titanium structures. The samples were sintered in argon atmosphere at 1200 ° C, 1300 ° C or 1400 ° C, resulting in total porosities ranging between 72.3% and 77.7%. A correlation was found between the total porosity and the elastic modulus of the scaffolds. The stiffness and yield strength were similar to those of cancellous bone. The functionalization of the scaffold surface with a cell adhesion fibronectin recombinant fragment resulted in enhanced adhesion and spreading of osteoblastic-like cells, together with increased alkaline phosphatase expression and mineralization. |
| Databáze: | OpenAIRE |
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