Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications
| Autor: | Jason R. McCarthy, Rajendran J.C. Bose, Intan Diana Mat Azmi, Yan Shan Loo, Thiagarajan Madheswaran |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Drug Carriers Vaccines Biomimetic materials business.industry Bioengineering Nanotechnology Bacterial Physiological Phenomena Nanostructures 03 medical and health sciences Drug Delivery Systems 030104 developmental biology 0302 clinical medicine Biomimetic Materials Biomimetics 030220 oncology & carcinogenesis Drug Discovery Drug delivery Humans Medicine Nanocarriers business Virus Physiological Phenomena |
| Zdroj: | Drug Discovery Today. 26:902-915 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2020.12.017 |
| Popis: | Smart nanocarriers obtained from bacteria and viruses offer excellent biomimetic properties which has led to significant research into the creation of advanced biomimetic materials. Their versatile biomimicry has application as biosensors, biomedical scaffolds, immobilization, diagnostics, and targeted or personalized treatments. The inherent natural traits of biomimetic and bioinspired bacteria- and virus-derived nanovesicles show potential for their use in clinical vaccines and novel therapeutic drug delivery systems. The past few decades have seen significant progress in the bioengineering of bacteria and viruses to manipulate and enhance their therapeutic benefits. From a pharmaceutical perspective, biomimetics enable the safe integration of naturally occurring bacteria and virus particles to achieve high, stable rates of cellular transfection/infection and prolonged circulation times. In addition, biomimetic technologies can overcome safety concerns associated with live-attenuated and inactivated whole bacteria or viruses. In this review, we provide an update on the utilization of bacterial and viral particles as drug delivery systems, theranostic carriers, and vaccine/immunomodulation modalities. |
| Databáze: | OpenAIRE |
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