Hereditary Polycystic Kidney Disease Associated with Osteorenal Syndrome in Rats
| Autor: | K. G. Rapp, F. Deerberg, J. Kaspareit-Rittinghausen, A. Wcislo, C. Messow |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
0301 basic medicine Heterozygote medicine.medical_specialty 040301 veterinary sciences Kidney Blood Urea Nitrogen Enteritis 0403 veterinary science 03 medical and health sciences Cecum Internal medicine medicine Polycystic kidney disease Animals Blood urea nitrogen Chronic Kidney Disease-Mineral and Bone Disorder Polycystic Kidney Diseases Sex Characteristics Hyperparathyroidism General Veterinary Metastatic calcification business.industry Homozygote Calcinosis Heterozygote advantage 04 agricultural and veterinary sciences medicine.disease Pedigree Rats Disease Models Animal Phenotype 030104 developmental biology medicine.anatomical_structure Endocrinology Kidney Failure Chronic Female Hyperparathyroidism Secondary Secondary hyperparathyroidism business |
| Zdroj: | Veterinary Pathology. 26:195-201 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098588902600302 |
| Popis: | Hereditary polycystic kidney disease (PKD) was seen in Han: SPRD rats and identified as an autosomal, incomplete dominant trait. Homozygous animals died at 3 to 4 weeks of age, while heterozygous males were severely ill or moribund within about 6 months. Heterozygous females developed PKD to a lesser extent than males and survived longer. Renal secondary hyperparathyroidism and osteodystrophia fibrosa were seen in most males but were absent in females. In male rats metastatic calcification was found in kidneys, lungs, glandular and forestomach, blood vessels, and heart. In a few uremic males ulcerative enteritis occurred in cecum and colon. Blood urea nitrogen values were significantly increased in both sexes. |
| Databáze: | OpenAIRE |
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