Vitamin E treatment of haemolytic uraemic syndrome
| Autor: | H R Powell, Rowan G. Walker, D A McCredie, C M Taylor, J R Burke |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Urinalysis medicine.medical_treatment Pilot Projects Gastroenterology law.invention Lipid peroxidation chemistry.chemical_compound Randomized controlled trial law Internal medicine Humans Vitamin E Medicine Child Creatinine medicine.diagnostic_test business.industry Infant Natural history Endocrinology Blood pressure chemistry Child Preschool Hemolytic-Uremic Syndrome Pediatrics Perinatology and Child Health Female business Research Article |
| Zdroj: | Archives of Disease in Childhood. 59:401-404 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.59.5.401 |
| Popis: | Because low plasma vitamin E concentrations have been reported in patients with haemolytic uraemic syndrome and there is accumulating evidence of lipid peroxidation in this disease, treatment with the antioxidant vitamin E was undertaken in 16 consecutive children with the syndrome. Twelve children had features at presentation suggesting a poor prognosis for recovery but despite this all 16 patients survived and are well three months later. Fifteen children now have normal values for serum creatinine, blood pressure, and urinalysis for protein but one has slight renal impairment. Although this is not a report of a controlled trial, it seems that patients treated with vitamin E have fared considerably better than our previously treated patients with haemolytic uraemic syndrome, even in the presence of early, adverse prognostic features. We suggest that vitamin E alters the natural history of the disease, and in view of the absence of any observed side effects further experience with this treatment is being sought. |
| Databáze: | OpenAIRE |
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