Effects of autotransfusion of mediastinal shed blood on biochemical markers of myocardial damage in coronary surgery
| Autor: | Stian Lydersen, Arne Åsberg, Roar Stenseth, Ole Tjomsland, Alexander Wahba, Ola Dale, Hilde Pleym, Lise Bjella |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Fatty Acid-Binding Proteins law.invention Blood Transfusion Autologous Necrosis Coronary artery bypass surgery Postoperative Complications Troponin T Troponin complex law Internal medicine medicine Cardiopulmonary bypass Humans Prospective Studies Myocardial infarction Coronary Artery Bypass Creatine Kinase Aged biology business.industry Myocardium Mediastinum General Medicine Middle Aged medicine.disease Troponin Anesthesiology and Pain Medicine medicine.anatomical_structure biology.protein Cardiology Female Creatine kinase Cardiomyopathies business Biomarkers Artery Autotransfusion |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 49:1248-1254 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | Background: Previous studies have shown conflicting results regarding the effect of autotransfusion of mediastinal shed blood after coronary artery bypass grafting (CABG) on the serum levels of myocardial band (MB) isoenzymes of creatine kinase (CK-MB) and cardiac troponins. The effect of autotransfusion on serum levels of human heart fatty acid binding protein (H-FABP), another marker of myocardial necrosis, has not been studied. The aim of the present study was to investigate the effects of autotransfusion of mediastinal shed blood on the serum levels of CK-MB, cardiac troponin T (cTnT), and H-FABP after uncomplicated primary CABG. Methods: Fifty patients were randomized to post-operative autotransfusion of mediastinal shed blood or no autotransfusion. Blood samples for the analysis of the biochemical markers of myocardial damage were drawn pre-operatively and 1, 4, 12, 24, 48, and 72 h after the termination of cardiopulmonary bypass. Samples from the mediastinal shed blood were collected after 1 and 4 h. Results: The levels of the biochemical markers of myocardial injury were all markedly elevated in mediastinal shed blood. Autotransfusion did not significantly affect the serum levels of cTnT or H-FABP. However, during the early post-operative hours, there was a trend towards a higher level of cTnT and H-FABP in the autotransfusion group. During the first 24 h after surgery, the autotransfusion group had a significantly higher serum level of CK-MB. Conclusion: Post-operative autotransfusion of mediastinal shed blood may contribute to elevated serum levels of biochemical markers of myocardial injury. |
| Databáze: | OpenAIRE |
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