Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies
| Autor: | A Kahan, F Picard, C J Menkes, B Amor |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Systemic disease medicine.drug_class T cell Immunology Fluorescent Antibody Technique Monoclonal antibody General Biochemistry Genetics and Molecular Biology Scleroderma Flow cytometry Rheumatology Antigens CD T-Lymphocyte Subsets Histocompatibility Antigens medicine Humans Immunology and Allergy Scleroderma Systemic medicine.diagnostic_test biology business.industry Integrin beta1 Antibodies Monoclonal T lymphocyte Flow Cytometry medicine.disease Antigens Differentiation medicine.anatomical_structure biology.protein Leukocyte Common Antigens Female business Phycoerythrin CD8 Research Article |
| Zdroj: | Annals of the Rheumatic Diseases. 50:354-358 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.50.6.354 |
| Popis: | T cell subpopulations were assessed by two colour flow cytometry with phycoerythrin conjugated anti-CD45RA and anti-CD29 and fluorescein conjugated anti-CD4 and anti-CD8 monoclonal antibodies, on peripheral blood lymphocytes from 12 patients with systemic sclerosis and from nine control subjects. The percentage of CD4+CD29+ cells was significantly higher in patients with systemic sclerosis than in controls (mean (SEM) 68.8 (3.1) v 47.9 (4.1) respectively). CD4+CD45RA+ cells were not significantly different in patients and controls. CD8+CD29+ and CD8+CD45RA+ subpopulations were significantly higher in patients with systemic sclerosis than in controls (83.0 (3.2) v 58.7 (6.8) and 80.2 (3.0) v 66.9 (3.2) respectively). The increase in the percentage of CD29+ cells suggests an activation of memory cells in patients with systemic sclerosis, which may play an important part in the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
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