Docosahexaenoic acid induces changes in microglia/macrophage polarization after spinal cord injury in rats
| Autor: | I. V. Dyuizen, Anna Tyrtyshnaia, Igor Manzhulo, Olga Manzhulo, Yulia O. Kipryushina |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Histology Antioxidant Docosahexaenoic Acids medicine.medical_treatment Central nervous system Antioxidants 03 medical and health sciences Superoxide Dismutase-1 0302 clinical medicine Internal medicine medicine Animals Spinal cord injury Cells Cultured Spinal Cord Injuries Cell Proliferation CD86 Staining and Labeling Microglia Chemistry Macrophages Cell Biology General Medicine Spinal cord medicine.disease Immunohistochemistry Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Spinal Cord Docosahexaenoic acid Female B7-2 Antigen CD163 030217 neurology & neurosurgery |
| Zdroj: | Acta Histochemica. 120:741-747 |
| ISSN: | 0065-1281 |
| Popis: | Docosahexaenoic acid (DHA, 22:6 (n-3)) leads to recovery of locomotor functions observed of spinal cord injury (SCI) in rats. In present study, we characterized the expression of iba-1, CD86, CD163 in microglia/macrophages, to assess activation state and M1 (pro-inflammatory)/M2 (anti-inflammatory) phenotypes respectively, in the rostral, central and caudal segment of the spinal cord on 7 and 35 days after SCI. We found that DHA treatment leads to: (1) an increased activation and proliferation of microglial cells; (2) an alteration in the dynamics between M1 and M2 microglia/macrophages phenotypes (3) and increased production of an antioxidant enzymes. Overall, our data demonstrates that DHA has a complex effect in post-traumatic process within the central nervous system, and supports the therapeutic potential of DHA-based drugs. |
| Databáze: | OpenAIRE |
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