Genetic susceptibility to invasive pneumococcal disease
| Autor: | Esther Calbo, Anna Sangil, Laura Ibanez, Maite Pérez, Javier Garau, Roberto Güerri-Fernández, Antoni Payeras, Jorge Torviso, María Jesús Arranz, Marta Andrés, Helena Monzón |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Oncology medicine.medical_specialty Pneumococcal disease Adolescent Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Microbiology Pneumococcal Infections Young Adult 03 medical and health sciences Internal medicine Genotype Genetics medicine Genetic predisposition Humans SNP Genetic Predisposition to Disease Molecular Biology Ecology Evolution Behavior and Systematics Aged Aged 80 and over Case-control study Middle Aged bacterial infections and mycoses NFKBIE Immunity Innate 030104 developmental biology Infectious Diseases Case-Control Studies Cohort Cytokines Female |
| Zdroj: | Infection, Genetics and Evolution. 59:126-131 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2018.01.024 |
| Popis: | Background The pathogenesis of IPD remains unknown, especially among middle-aged individuals without risk factors (WRF). Objectives The aim of the present study was to investigate the role of single nucleotide polymorphisms (SNP) within key genes involved in innate immune response on IPD susceptibility. Methods Forty-three SNPs within 10 immunological genes were investigated in a cohort of 144 Caucasian IPD patients and 280 ethnically matched controls. Results The allele distribution of the NFKBIA rs1050851 and NFKBIE rs2282151 variants were associated with IPD susceptibility (χ2 = 4.23, p = 0.04 and χ2 = 5.13, p = 0.02, respectively). Additionally, the genotype distribution of NFKBIZ rs645781 (χ2 = 8.25, p = 0.02) and IL1R1 rs3917254 (χ2 = 6.70, p = 0.04) were also associated with IPD risk. When only IPD-WRF patients were considered; the allele distribution of IL1R1 rs2160227 (χ2 = 5.62, p = 0.03), rs13020778 (χ2 = 5.73, p = 0.02), rs3917267 (χ2 = 3.72, p = 0.05) and IL4 rs2227284 (χ2 = 3.76, p = 0.05) and the genotype distribution of IL10 rs3024509 (χ2 = 7.70, p = 0.02), IL1R1 rs3917254 (χ2 = 13.40, p = 0.001), NFKBIZ rs645781 (χ2 = 13.86, p = 0.001) and rs677011 (χ2 = 9.06, p = 0.01) variants were associated with IPD risk. Conclusions We found several associations between variants in the IL1R1, IL4, IL10, NFKBIE, NFKBIA, and NFKBIZ genes and risk of IPD. If validated, these biomarkers may help to identify people with higher risk of IPD. |
| Databáze: | OpenAIRE |
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