Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection
| Autor: | David E. Stephens, Carlos M. Restrepo, Ricardo Lleonart, Hang T. Dang, L Herrera, Oleg V. Larionov, Jennifer Álvarez, Patricia L. Fernández, Kissy Degracia, Alejandro Llanes, René Rivera |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject 030231 tropical medicine Antiprotozoal Agents Quinoline derivative Inflammation Pharmacology Biology Parasite load Article lcsh:Infectious and parasitic diseases BALB/c Mice 03 medical and health sciences 0302 clinical medicine Chloroquine medicine Animals lcsh:RC109-216 Pharmacology (medical) Leishmaniasis media_common Leishmania Mice Inbred BALB C medicine.disease biology.organism_classification Mice Inbred C57BL Disease Models Animal 030104 developmental biology Infectious Diseases Pharmaceutical Preparations Toxicity Female Parasitology medicine.symptom medicine.drug |
| Zdroj: | International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss, Pp 56-61 (2020) International Journal for Parasitology: Drugs and Drug Resistance |
| ISSN: | 2211-3207 |
| Popis: | Leishmania panamensis is a relevant causative agent of tegumentary leishmaniasis in several Latin American countries. Available antileishmanial drugs have several limitations including relatively high toxicity, difficult administration, high production costs and the emergence of resistance in circulating strains. Therefore, the identification of new molecules as potential therapeutics for leishmaniasis is of great relevance. Here, we developed a murine model of L. panamensis infection and evaluated the effect of a new compound in vivo. After treatment of animals with the compound, we observed a significant reduction of inflammation and parasite load at the inoculation site, in a dose-dependent manner. We observed a reduction in IL-10 production by popliteal lymph nodes cells of infected mice. These results pave the way for future evaluation of this compound as a potential antileishmanial drug or as a suitable scaffold for lead optimization strategies. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|