Exercise and Diet Induced Weight Loss Attenuates Oxidative Stress Related-Coronary Vasoconstriction in Obese Adolescents
Autor: | Ronald J. Williams, Zhaohui Gao, Urs A. Leuenberger, Matthew D. Muller, Lawrence I. Sinoway, Samson Spilk, Marsha B. Novick |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty Adolescent Physiology Diet therapy Doppler echocardiography medicine.disease_cause Article Coronary circulation Weight loss Physiology (medical) Internal medicine Coronary Circulation medicine Humans Orthopedics and Sports Medicine Obesity Hyperoxia medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health Coronary Stenosis General Medicine Combined Modality Therapy Coronary Vessels Exercise Therapy Oxidative Stress medicine.anatomical_structure Blood pressure Treatment Outcome Vasoconstriction Anesthesia Cardiology medicine.symptom business Oxidative stress Blood Flow Velocity Diet Therapy |
Popis: | Obesity is a disease of oxidative stress (OS). Acute hyperoxia (breathing 100% O2) can evoke coronary vasoconstriction by the oxidative quenching of nitric oxide (NO). To examine if weight loss would alter the hyperoxia related-coronary constriction seen in obese adolescents, we measured the coronary blood flow velocity (CBV) response to hyperoxia using transthoracic Doppler echocardiography before and after a 4-week diet-and-exercise regimen in 6 obese male adolescents (age 13–17 yrs, BMI, 36.5 ± 2.3 kg/m2). Six controls of similar age and BMI were also studied. The intervention group lost 9 ± 1% body weight, which was associated with a reduced resting heart rate (HR), reduced diastolic blood pressure (BP), and reduced rate pressure product (RPP, all P |
Databáze: | OpenAIRE |
Externí odkaz: |