Exercise and Diet Induced Weight Loss Attenuates Oxidative Stress Related-Coronary Vasoconstriction in Obese Adolescents

Autor: Ronald J. Williams, Zhaohui Gao, Urs A. Leuenberger, Matthew D. Muller, Lawrence I. Sinoway, Samson Spilk, Marsha B. Novick
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Popis: Obesity is a disease of oxidative stress (OS). Acute hyperoxia (breathing 100% O2) can evoke coronary vasoconstriction by the oxidative quenching of nitric oxide (NO). To examine if weight loss would alter the hyperoxia related-coronary constriction seen in obese adolescents, we measured the coronary blood flow velocity (CBV) response to hyperoxia using transthoracic Doppler echocardiography before and after a 4-week diet-and-exercise regimen in 6 obese male adolescents (age 13–17 yrs, BMI, 36.5 ± 2.3 kg/m2). Six controls of similar age and BMI were also studied. The intervention group lost 9 ± 1% body weight, which was associated with a reduced resting heart rate (HR), reduced diastolic blood pressure (BP), and reduced rate pressure product (RPP, all P
Databáze: OpenAIRE