Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy
| Autor: | Chin Sung Chang, Po Wei Chen, Chih Hsing Wu, Jia Rong Yu, Wei-Chuan Tsai, Ping Yen Liu, Ling Wei Hsu, Wei Ting Chang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Male Serum medicine.medical_specialty endocrine system Sarcopenia Calcification inhibitor endocrine system diseases alpha-2-HS-Glycoprotein Taiwan 030204 cardiovascular system & hematology Left ventricular hypertrophy Sensitivity and Specificity Article Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Humans Vitamin D Wasting Aged Aged 80 and over Multidisciplinary business.industry Diastolic heart failure Odds ratio medicine.disease Suburban Population 030104 developmental biology Endocrinology Parathyroid Hormone Female Hypertrophy Left Ventricular medicine.symptom business human activities hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | With aging, intact parathyroid hormone (iPTH) increases. It plays a crucial role in left ventricular hypertrophy (LVH). Also, 25-hydroxy vitamin D (Vit-D) and iPTH have been observed to be determinants of muscle wasting known as sarcopenia. Fetuin A (FetA), a systemic calcification inhibitor, involves in the development of diastolic heart failure. Hence, we hypothesized that the interplay among FetA, Vit-D and iPTH may contribute to sarcopenic LVH among the elders. We analyzed a database from the Tianliao Old People study with 541 elders (≥65 years) in a Taiwan’s suburban community. After excluding patients with renal function impairment, 120/449 (26.7%) patients were diagnosed with sarcopenia. Sarcopenic patients had lower serum Vit-D levels but higher FetA as well as iPTH. Notably, sarcopenic patients with LVH had significantly lower FetA and higher iPTH levels. In multivariate logistic regression analysis, only the increase in iPTH was independently associated with sarcopenic LVH (Odds ratio: 1.05; confidence interval: 1.03–1.08, p = 0.005). Using iPTH >52.3 ng/l as a cutoff point, the sensitivity and specificity was 66% and 84%, respectively. In conclusion, FetA, Vit-D, and iPTH levels were all associated with sarcopenia in this geriatric population. Among them, iPTH specifically indicates patients with sarcopenic LVH. |
| Databáze: | OpenAIRE |
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