Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems
| Autor: | Paolo Bertoncin, Anna Angela Barba, Annalisa Dalmoro, Gaetano Lamberti, Veronica De Simone, Sabrina Bochicchio |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Novel technique
Aging Materials science media_common.quotation_subject Microfluidics Pharmaceutical Science Nanotechnology 02 engineering and technology Dermatology Cosmetics lcsh:Chemistry 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Chemical Engineering (miscellaneous) media_common Active ingredient Liposome 021001 nanoscience & nanotechnology cosmeceutics antioxidants lcsh:QD1-999 simil-microfluidic technology nanoliposomes Surgery transdermal delivery 0210 nano-technology Cosmeceutical |
| Zdroj: | Cosmetics Volume 7 Issue 2 Cosmetics, Vol 7, Iss 22, p 22 (2020) |
| ISSN: | 2079-9284 |
| DOI: | 10.3390/cosmetics7020022 |
| Popis: | Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84&ndash 145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field. |
| Databáze: | OpenAIRE |
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