Evaluation of Early Onset Sepsis, Complete Blood Count, and Antibiotic Use in Gastroschisis
| Autor: | Matthew Leonard, Sadie L. Williams, Jacqueline Wessel, Eric S. Hall, Jose Perez, Paul S. Kingma |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neutrophils Population Article Sepsis Abdominal wall 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans 030212 general & internal medicine education Retrospective Studies Gastroschisis education.field_of_study medicine.diagnostic_test business.industry Incidence (epidemiology) Abdominal Wall Infant Newborn Obstetrics and Gynecology Complete blood count Reproducibility of Results Retrospective cohort study medicine.disease United States Surgery Anti-Bacterial Agents Blood Cell Count medicine.anatomical_structure Case-Control Studies Pediatrics Perinatology and Child Health Absolute neutrophil count Female business |
| Zdroj: | American journal of perinatology. 35(4) |
| ISSN: | 1098-8785 |
| Popis: | Objective Gastroschisis is a congenital defect in which the abdominal viscera herniate through the abdominal wall. In this population, antibiotics are often initiated immediately following delivery; however, this may be unnecessary as infections typically develop as a consequence of chronic issues in gastroschisis. The objective of this study was to evaluate the incidence of culture positive early onset sepsis, the reliability of the immature to mature neutrophil count (I:T) ratio as an infectious biomarker, and antibiotic use in infants with gastroschisis. Study Design This retrospective chart review analyzed clinical data from 103 infants with gastroschisis and 103 weight-matched controls that were evaluated for early onset infection. Results Compared with the control group, there was a significantly increased percentage of infants with an I:T ratio > 0.2 in the gastroschisis group (43% vs. 12%, p Conclusion Our results indicate that I:T ratio is not a reliable marker of infection in gastroschisis, and suggest that empiric septic evaluation and antibiotic use, immediately following delivery in gastroschisis infants, may be unnecessary. |
| Databáze: | OpenAIRE |
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