Welding Fume Exposure and Epigenetic Alterations: A Systematic Review
| Autor: | Caterina Nocera, Ivo Iavicoli, Ilaria Vetrani, Ilaria Della Volpe, Veruscka Leso |
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| Přispěvatelé: | Leso, V., Vetrani, Ilaria, DELLA VOLPE, Ilaria, Nocera, Caterina, Iavicoli, I. |
| Rok vydání: | 2019 |
| Předmět: |
epigenetic effects
Health Toxicology and Mutagenesis epigenome lcsh:Medicine Air Pollutants Occupational Review Biological indicator Bioinformatics risk management Occupational safety and health Epigenesis Genetic 03 medical and health sciences health effects Medicine Humans Welding Epigenetics Gene 030304 developmental biology Exposure assessment particulate matter 0303 health sciences Inhalation Exposure DNA methylation business.industry lcsh:R Public Health Environmental and Occupational Health 030311 toxicology risk assessment Environmental exposure Epigenome occupational exposure biological indicators Epigenetic effect Health effect F2RL3 welding fumes Gases business |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 16, Iss 10, p 1745 (2019) |
| ISSN: | 1660-4601 |
| Popis: | Epigenetics are heritable changes in gene expression not coded in the DNA sequence, which stand at the interface between the genome, environmental exposure and development. From an occupational health perspective, epigenetic variants may link workplace exposures and health effects. Therefore, this review aimed to overview possible epigenetic effects induced by welding fumes on exposed workers and health implications. A systematic search was performed on Pubmed, Scopus, and ISI Web of Knowledge databases. DNA methylation changes have been reported in genes responsible for the cardiac autonomic function and coagulation, i.e., LINE-1, GPR133 and F2RL3, in mitochondrial-DNA-sequences involved in the regulation of energy-generation/redox-signaling, as well as in inflammatory activated genes, i.e., iNOS. However, the limited number of retrieved articles, their cross-sectional nature, the lack of a suitable qualitative-quantitative exposure assessment, and the heterogeneity of biological-outcomes investigated, prevent the extrapolation of a definite causal relationship between welding fumes and epigenetic phenomena. Future studies should clarify the function of such epigenetic alterations as possible markers of occupational exposure and early effect, dose-response relationships, and underlying molecular mechanisms. Overall, this may be helpful to guide suitable risk assessment and management strategies to protect the health of workers exposed to welding fumes. |
| Databáze: | OpenAIRE |
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