Action observation training modifies brain gray matter structure in healthy adult individuals
| Autor: | Elisabetta Pagani, Massimo Filippi, Andrea Falini, Paolo Preziosa, Silvia Fumagalli, Roberto Gatti, Giancarlo Comi, Gianna C Riccitelli, Maria A. Rocca |
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| Přispěvatelé: | Rocca, Ma, Fumagalli, S, Pagani, E, Gatti, R, Riccitelli, Gc, Preziosa, P, Comi, G, Falini, A, Filippi, Massimo |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Cognitive Neuroscience Motion Perception Audiology 050105 experimental psychology White matter 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine Neural Pathways Motor system Neuroplasticity medicine Humans Learning 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Longitudinal Studies Gray Matter Neuronal Plasticity 05 social sciences Neuropsychology Brain Cognition Organ Size Hand Magnetic Resonance Imaging Cognitive test Psychiatry and Mental health medicine.anatomical_structure Neurology Motor Skills Female Neurology (clinical) Brain Gray Matter Psychology Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Brain Imaging and Behavior. 11:1343-1352 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | Action observation training (AOT) is thought to facilitate motor system function. We applied voxelwise methods to assess the regional modifications of brain gray matter (GM) volumes and white matter (WM) architecture in healthy subjects following AOT and their correlations with improvements at motor and cognitive functional scales. Forty-two righ-handed healthy subjects were randomized into an experimental (AOT-G, n = 20) and a control (C-G, n = 22) group. The training lasted 2 weeks and consisted of 10 sessions of 45 min each during which subjects watched videos of daily-life actions (AOT-G) or landscapes (C-G), alternated by the execution with the right hand of actions presented in the AOT-G videos. At baseline and follow up, motor and cognitive functional measures as well as brain structural MRI scans were obtained. Tensor-based morphometry and tract-based spatial statistics were used to map longitudinal modifications of GM and WM structures and their correlation with functional scales. After training, both groups improved at cognitive tests, whereas the AOT-G also improved hand motor performance. Following training, no modifications of WM diffusion tensor MRI indexes were detected. After training, compared to C-G, AOT-G had increased volume of the left superior frontal gyrus and decreased volume of the right lingual gyrus. Compared to AOT-G, C-G showed increased volume of the right middle frontal gyrus and left inferior temporal gyrus. In AOT-G, GM volume changes correlated with improvements at cognitive tests. Ten-day AOT in healthy individuals modifies GM structure, promoting structural brain plasticity and functional competence. |
| Databáze: | OpenAIRE |
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