Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations

Autor: James D. Crapo, Alex J. Barker, Brett E. Fenster, Uyen Truong, Vitaly O. Kheyfets, Kurt R. Stenmark, Michal Schäfer, Michael E. Yeager, J. Kern Buckner, Kendall S. Hunter
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Cardiac Catheterization
medicine.medical_treatment
Heart Ventricles
Hypertension
Pulmonary
Magnetic Resonance Imaging (MRI)
Hemodynamics
Magnetic Resonance Imaging
Cine
030204 cardiovascular system & hematology
Pulmonary Artery
hemodynamics
030218 nuclear medicine & medical imaging
Imaging
03 medical and health sciences
0302 clinical medicine
Afterload
Internal medicine
medicine.artery
pulmonary hypertension
medicine
Image Processing
Computer-Assisted
Humans
magnetic resonance imaging
Prospective Studies
Pulmonary Wedge Pressure
Pulmonary wedge pressure
Cardiac catheterization
Original Research
business.industry
Stroke Volume
Stroke volume
Vorticity
Middle Aged
medicine.disease
Pulmonary hypertension
Pulmonary artery
Cardiology
Ventricular Function
Right
flow imaging
Female
Cardiology and Cardiovascular Medicine
business
Blood Flow Velocity
Magnetic Resonance Angiography
Follow-Up Studies
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Qualitative and quantitative flow hemodynamic indexes have been shown to reflect right ventricular ( RV ) afterload and function in pulmonary hypertension ( PH ). We aimed to quantify flow hemodynamic formations in pulmonary arteries using 4‐dimensional flow cardiac magnetic resonance imaging and the spatial velocity derivatives helicity and vorticity in a heterogeneous PH population. Methods and Results Patients with PH (n=35) and controls (n=10) underwent 4‐dimensional flow magnetic resonance imaging study for computation of helicity and vorticity in the main pulmonary artery ( MPA ), the right pulmonary artery, and the RV outflow tract. Helicity and vorticity were correlated with standard RV volumetric and functional indexes along with MPA stiffness assessed by measuring relative area change. Patients with PH had a significantly decreased helicity in the MPA (8 versus 32 m/s 2 ; P 2 ; P RV outflow tract– MPA unit (15 versus 42 m/s 2 ; P P P RV ejection fraction (0.865; P P P =0.0008), and relative area change measured at the MPA (0.789; P Conclusions The flow hemodynamic character in patients with PH assessed via quantitative analysis is considerably different when compared with healthy and normotensive controls. A strong association between helicity in pulmonary arteries and ventricular‐vascular coupling suggests a relationship between the mechanical and flow hemodynamic domains.
Databáze: OpenAIRE
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