Metabolic syndrome associates with left atrial dysfunction

Autor: Markku O. Pentikäinen, Marja-Riitta Taskinen, Nina Lundbom, Kirsi Lauerma, Marit Granér, Jesper Lundbom, Markku S. Nieminen, Reijo Siren, Antti Hakkarainen, Kristofer Nyman
Přispěvatelé: Department of Diagnostics and Therapeutics, University of Helsinki, Clinicum, HUS Medical Imaging Center, HUS Heart and Lung Center, Marja-Riitta Taskinen Research Group, Kardiologian yksikkö, Diabetes and Obesity Research Program, Research Programs Unit, Department of Medicine, Department of General Practice and Primary Health Care, HUS Internal Medicine and Rehabilitation
Rok vydání: 2018
Předmět:
Male
obesity
Proton Magnetic Resonance Spectroscopy
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Adipose tissue
030204 cardiovascular system & hematology
Ventricular Function
Left
030218 nuclear medicine & medical imaging
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
visceral adipose tissue
ejection fraction
Adiposity
Metabolic Syndrome
2. Zero hunger
Nutrition and Dietetics
Ejection fraction
Atrial fibrillation
Middle Aged
Magnetic Resonance Imaging
3. Good health
Liver
cardiac steatosis
Obesity
Abdominal
Cardiology
Atrial Function
Left
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Heart Diseases
Subcutaneous Fat
Intra-Abdominal Fat
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Humans
Triglycerides
Triglyceride
business.industry
Myocardium
Atrial Remodeling
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
Obesity
Cross-Sectional Studies
chemistry
3121 General medicine
internal medicine and other clinical medicine
Case-Control Studies
left atrial
Cardiovascular magnetic resonance
Insulin Resistance
Metabolic syndrome
business
Body mass index
Biomarkers
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 28:727-734
ISSN: 0939-4753
Popis: Background and aims: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. Methods and results: Myocardial and hepatic triglyceride contents were measured with 1.5T H-1-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS. LA volumes were assessed using a novel three-chamber orientation based MRI approach. LA ejection fraction (EF) was lower in MetS patients than in the control group (44 +/- 7.7% in MetS vs. 49 +/- 8.6% in controls, p = 0.013) without LA enlargement, indicating LA dysfunction. LA EF correlated negatively with waist circumference, body mass index, SAT, VAT, fasting serum insulin, and homeostasis model assessment of insulin resistance index, and positively with fasting serum high-density lipoprotein cholesterol. VAT was the best predictor of reduced LA EF. Conclusions: MetS associates with subclinical LA dysfunction. Multiple components of MetS are related to LA dysfunction, notably visceral obesity and insulin resistance. Further studies are needed to elucidate the role of mechanical atrial remodeling in the development of AF. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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