Clarithromycin laurate salt: physicochemical properties and pharmacokinetics after oral administration in humans
| Autor: | Nader Al Bujuq, Mohammad Saleh, Yasser Bustanji, Saja Hamed, Susana Torrado-Susana, Alsayed Sallam, Bashar A. Alkhalidi, Hatim S. AlKhatib, Naji M. Najib |
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| Rok vydání: | 2018 |
| Předmět: |
Administration
Oral Pharmaceutical Science Salt (chemistry) 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Stability Pharmacokinetics Oral administration Clarithromycin polycyclic compounds medicine Humans chemistry.chemical_classification Fatty acid General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses 021001 nanoscience & nanotechnology Anti-Bacterial Agents Bioavailability Solubility chemistry Salts 0210 nano-technology Laurates Tablets medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. 24:607-615 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | To prepare and characterize the physicochemical and pharmacokinetic properties of clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM).CLM-L was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR,CLM-L showed lower aqueous solubility, higher partitioning coefficient, and slower dissolution rate. Tablets of CLM-L also showed a significantly slower in vitro release in comparison to CLM tablets. CCLM-L was successfully prepared and its formation was confirmed. CLM-L was more hydrophobic than CLM. It exhibited a slight in vivo absorption enhancement in comparison to CLM. However, its pharmacokinetic behavior was comparable to that of CLM. |
| Databáze: | OpenAIRE |
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