Synthesis, Characterization and Anti-inflammatory Activity of N-(4- phenyl-1, 3-thiazol-2-yl)-N'-phenylureas
| Autor: | Ravindra Kulkarni, Aneesa Fatima, Asief Mohammed, Bhagavanraju Mantripagada, V.M. Chandrasheskar, Anusaya Birajdar |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Chemistry Stereochemistry medicine.drug_class Phenylurea Compounds Immunology Anti-Inflammatory Agents Phenylurea Derivatives Active site General Medicine Carrageenan Anti-inflammatory Rats chemistry.chemical_compound biology.protein Urea Proton NMR medicine Animals Edema Immunology and Allergy Spectral data |
| Zdroj: | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 13:112-120 |
| ISSN: | 1871-5230 |
| DOI: | 10.2174/1871523013666140820154843 |
| Popis: | A series of N-(4-phenyl-1, 3-thiazol-2-yl)-N'- phenylureas (5a-z) was synthesized from 2-amino-4-substituted phenylthiazoles and phenylisocyanates. The newly synthesized compounds were characterized by IR, (1)H NMR and Mass spectral data. All the twenty six N-(4-phenyl-1, 3-thiazol-2-yl)-N'-phenylurea derivatives were screened for antiinflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, N-[4- (4-methoxy phenyl)-1, 3-thiazol-2-yl)-N'-phenylurea and N-[4-(4-methoxy phenyl-1, 3-thiazol-2-yl)-N'-(4-bromophenyl) urea were found to be more potent. The molecular docking interaction of aforementioned urea compounds revealed the traditional type II p38 kinase inhibitor's interactions in the DFG out active site. |
| Databáze: | OpenAIRE |
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