Sex-related differences and hormonal effects in the Dry Eye Assessment and Management (DREAM) study
| Autor: | Megan Zhao, Yinxi Yu, Neeta S Roy, Gui-shuang Ying, Penny Asbell, Vatinee Y Bunya |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | British Journal of Ophthalmology. :bjo-2022 |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | Background/aimsTo compare dry eye disease (DED) signs and symptoms between men and women, as well as between premenopausal and postmenopausal women, in the Dry Eye Assessment and Management (DREAM) study.Methods434 women and 101 men self-reported prior medical history and underwent a standardised DED assessment using the Ocular Surface Disease Index, Brief Pain Inventory, Tear Break-Up Time (TBUT)(s), Schirmer’s test 2 (mm/5 min), National Eye Institute-graded lissamine conjunctival staining, corneal staining, meibomian gland dysfunction evaluation and tear osmolarity (mOsms/L) at baseline, 6 months and 12 months. Multivariable linear regression models were used to compare these scores.ResultsWomen experienced significantly worse DED signs than men with lower Schirmer’s test scores (9.27 vs 12.16; pConclusionIn the DREAM study, women experienced more severe DED signs than men. Further, postmenopausal women presented with more severe DED signs than premenopausal women. Elucidating these differences may improve DED diagnosis and provide future direction in understanding sex-related differences in DED.Trial registration numberNCT02128763. |
| Databáze: | OpenAIRE |
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