Association study of interleukin-1 receptor associated kinase 1 rs3027898 A?C gene polymorphism and preeclampsia in Pakistani population
| Autor: | Hira Waqas Cheema, Amena Rahim, Yawar Zaman, Muhammad Afzal, Muhammad Imran Bajwa, Amna Mahmood |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Gastroenterology law.invention Interleukin-1 receptor-associated kinase 1 Preeclampsia Young Adult Pre-Eclampsia Pregnancy law Polymorphism (computer science) Internal medicine Genotype medicine Humans Pakistan Polymerase chain reaction Polymorphism Genetic business.industry Pakistani population Receptors Interleukin-1 Interleukin General Medicine medicine.disease Interleukin-1 Receptor-Associated Kinases Case-Control Studies Female Gene polymorphism business |
| Zdroj: | Journal of the Pakistan Medical Association. :1-14 |
| ISSN: | 0030-9982 |
| Popis: | Objectives To find the association between interleukin-1 receptor-associated kinase 1 rs3027898 gene polymorphism and preeclampsia. METHODS The case-control study was conducted from October, 2018 to September, 2019 at the Railway General Hospital and the Department of Biochemistry, Islamic International Medical College, Rawalpindi, Pakistan, and comprised patients diagnosed with preeclampsia and healthy controls. The interleukin receptor-associated kinase-1 polymorphism was determined using multiplex tetra primer amplification refractory mutation system polymerase chain reaction. Outcomes were determined in terms of association of interleukin receptor-associated kinase-1 with preeclampsia. Data was analysed using SPSS 22. RESULTS Of the 160 subjects, 80(50% were cases with a mean age of 30±5.3 years and 80(50%) were controls with a mean age of 27±3.7 years. AC genotype was seen in 45(56.25%) cases and 30(37.5%) controls, AA genotype in 25(31.25%) cases and 30(37.5%) controls, while CC genotype was seen in 10(12.5%) cases and 20(25%) controls (p>0.05). CONCLUSIONS There was no significant association of interleukin receptor-associated kinase-1 genotypes with preeclampsia. |
| Databáze: | OpenAIRE |
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