Endothelin blockade lowers total peripheral resistance in hemorrhagic shock recovery
| Autor: | M Maymind, R S Zimmerman, R W Barbee |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Cardiac output Mean arterial pressure business.industry Endothelins Hemodynamics Blood Pressure Thiobutabarbital Shock Hemorrhagic Peptides Cyclic Rats Rats Sprague-Dawley medicine.anatomical_structure Shock (circulatory) Anesthesia Internal Medicine Vascular resistance medicine Animals Vascular Resistance medicine.symptom Endothelin receptor business medicine.drug Blood vessel |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 23(2) |
| ISSN: | 0194-911X |
| Popis: | To determine whether endothelin (ET) has a role in maintaining circulatory support during hypotensive hemorrhage, we (1) examined cardiac and systemic hemodynamics after a 6-mL hemorrhage in the presence and absence of the ETA receptor blocker BQ-123, (2) examined cardiac and systemic hemodynamics during BQ-123 infusion in nonhemorrhaged rats, (3) measured changes in circulating immunoreactive endothelin (IR-ET) after a 6-mL hemorrhage, and (4) infused pathophysiological doses of ET-1 into rats anesthetized with thiobutabarbital. Twenty minutes after hemorrhage, cardiac output and mean arterial pressure had stabilized in part because of an increase in systemic vascular resistance from 0.86 +/- 0.04 (baseline) to 1.04 +/- 0.05 (20 minutes) mm Hg/mL per minute. The rise in systemic vascular resistance was temporally associated with a significant (24%) increase in circulating IR-ET from 29 +/- 2 to 36 +/- 3 pg/mL 20 minutes after hemorrhage. During BQ-123 infusion mean arterial pressure at 5, 10, and 20 minutes after hemorrhage was 9 +/- 2, 23 +/- 4, and 23 +/- 3 mm Hg lower than values obtained after hemorrhage alone (P < .05). Mean arterial pressure was unaffected by BQ-123 infusion at baseline and 30 minutes after hemorrhage. Systemic vascular resistance was not affected at baseline by BQ-123 infusion. However, systemic vascular resistance was significantly lower 5, 10, 20, and 30 minutes after hemorrhage during BQ-123 infusion compared with hemorrhage alone at each time point. Infusion of BQ-123 into nonhemorrhaged rats had no effect on mean arterial pressure, systemic vascular resistance, or cardiac output.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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