Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity
| Autor: | Philip J. Johnson, Giorgio Ballardini, Heather M. Smith, Roger Williams, B.M. McFarlane, I.G. McFarlane, F.B. Bianchi, C. Bridger, Diego Vergani, M. Lenzi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Autoimmune chronic active hepatitis Hepatitis C virus Enzyme-Linked Immunosorbent Assay Asialoglycoprotein Receptor Hepacivirus medicine.disease_cause Sampling Studies Autoimmune Diseases medicine Humans In patient False Positive Reactions Hepatitis Antibodies Receptors Immunologic Autoimmune liver disease Aged Autoantibodies Hepatitis Chronic Retrospective Studies Autoimmune disease Hepatitis Aged 80 and over biology business.industry virus diseases General Medicine Middle Aged medicine.disease Virology digestive system diseases United Kingdom Italy Immunoglobulin G Immunology biology.protein Female Antibody business |
| Zdroj: | Lancet (London, England). 338(8762) |
| ISSN: | 0140-6736 |
| Popis: | To resolve conflicting reports about the occurrence of antibodies against hepatitis C virus (HCV) in patients with autoimmune chronic active hepatitis (AI-CAH), sera from UK and Italian patients were tested with the original anti-HCV assay (Ortho) and a novel anti-HCV assay (UBI) based entirely on synthetic HCV peptides. 28 (60%) of 47 Italian patients with type-1 AI-CAH were anti-HCV-positive by Ortho ELISA, 25 of whom were also strongly positive by the UBI assay. 15 (60%) of 25 UK patients with type-1 AI-CAH were HCV-positive by Ortho ELISA but only 2 were positive by the UBI assay. Similarly, 29 (88%) of 33 Italian patients with type-2 AI-CAH, but 0 of 10 UK patients, were very strongly anti-HCV-positive with the UBI assay. Italian patients with AI-CAH appear to have a high frequency of genuine exposure to HCV, whereas seropositivity by the Ortho HCV ELISA in UK patients is likely to represent a false-positive result. These findings indicate important geographical and/or genetic influences in autoimmune liver disease among different populations. |
| Databáze: | OpenAIRE |
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