Two components in neurotoxicity by L-2-amino-3-phosphonopropionate in cultured cerebellar neurons
| Autor: | Antonello Novelli, M. Teresa Fernández-Sánchez, Angeles Torreblanca |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
6-Cyano-7-nitroquinoxaline-2 3-dione Neurons Alanine Metabotropic glutamate receptor 5 Cell Survival Metabotropic glutamate receptor 7 Metabotropic glutamate receptor 6 Biology Toxicology Receptors Metabotropic Glutamate Pollution Receptors N-Methyl-D-Aspartate Rats Metabotropic receptor Biochemistry Metabotropic glutamate receptor Cerebellum NMDA receptor Metabotropic glutamate receptor 1 Animals Metabotropic glutamate receptor 2 Dizocilpine Maleate Cells Cultured |
| Zdroj: | European journal of pharmacology. 270(4) |
| ISSN: | 0014-2999 |
| Popis: | Exposure of cultured cerebellar neurons to the putative metabotropic glutamate receptor antagonist L -2-amino-3-phosphono-propionate ( L -AP3) for 24 h produced a neurotoxic effect which was prevented by the addition of the NMDA receptor antagonist (+)-10, 11-dihydro-5H-dibenzo-[a, d]-cyclohepten-5, 10-imine hydrogen maleate (MK-801 did also reduce neurotoxicity following 72 h exposure to L -AP3. Residual L -AP3 neurotoxicity in the presence of MK-801 was antagonized by glutamate. Our results suggest that metabotropic glutamate receptors may play an important role in meuronal survival by controlling NMDA receptor-dependent as well as independent pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|