Materials for the stem cell factories of the future
| Autor: | Daniel G. Anderson, Adam D. Celiz, Martyn C. Davies, James G W Smith, Lorraine E. Young, Robert Langer, Morgan R. Alexander, Chris Denning, David A. Barrett, David A. Winkler |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Multiple Sclerosis
Computer science Cell Culture Techniques Drug Evaluation Preclinical Myocardial Infarction Biocompatible Materials Nanotechnology Diabetes Mellitus Screening programs Animals Humans General Materials Science Induced pluripotent stem cell Biomedicine business.industry Stem Cells Mechanical Engineering Scale (chemistry) Industrial scale General Chemistry Condensed Matter Physics Biocompatible material Billion Cells Risk analysis (engineering) Mechanics of Materials Stem cell business biomaterials cells human pluripotent stem cells Stem Cell Transplantation |
| ISSN: | 1476-1122 1476-4660 |
| Popis: | Polymeric substrates are being identified that could permit translation of human pluripotent stem cells from laboratory-based research to industrial-scale biomedicine. Well-defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large-scale drug-screening programs and clinical use. Yet more than 1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells is challenging, and a rethink of the current predominant cell-derived substrates is needed to provide technology that can be scaled to meet the needs of millions of patients a year. In this Review, we consider the role of materials discovery, an emerging area of materials chemistry that is in large part driven by the challenges posed by biologists to materials scientists. |
| Databáze: | OpenAIRE |
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