Time-Course Evaluation of Oxidative Stress-Related Biomarkers after Renal Transplantation

Autor:	Petr Schneiderka, Eva Orolinová, Markéta Kajabová, Adéla Galandáková, Josef Zadražil, Pavel Štrebl, Jana Zapletalová, Jitka Vostálová, Alena Rajnochová Svobodová
Rok vydání:	2012
Předmět:	Male medicine.medical_specialty Time Factors Population Renal function Kidney Function Tests Critical Care and Intensive Care Medicine Thiobarbituric Acid Reactive Substances Lipid peroxidation chemistry.chemical_compound Internal medicine TBARS Humans Medicine Prospective Studies education Kidney transplantation chemistry.chemical_classification education.field_of_study Creatinine Superoxide Dismutase business.industry Glutathione peroxidase General Medicine Middle Aged Prognosis medicine.disease Glutathione Kidney Transplantation Transplantation Oxidative Stress Endocrinology chemistry Nephrology Immunology Kidney Failure Chronic Female Lipid Peroxidation business Biomarkers Follow-Up Studies
Zdroj:	Renal Failure. 34:413-419
ISSN:	1525-6049 0886-022X
DOI:	10.3109/0886022x.2011.649658
Popis:	Patients with chronic renal disease have a high prevalence of oxidative stress (OS), which is associated with the cardiovascular complications occurring in this population. The restoration of kidney function after kidney transplantation (KT) can lead to reduction in the metabolic abnormalities and elimination of the OS. Time-dependent changes in OS-related markers and specific kidney function and metabolic parameters were evaluated in patients (N = 39; 23 males; 16 females; mean age = 57 ± 10 years) before (day 0) and after KT (day 1, 7, 30, 90, and 180) to monitor the graft. In particular, total antioxidant capacity (TAC), levels of advanced oxidation protein products (AOPP), lipid peroxidation as thiobarbituric acid-reactive substances (TBARS) and reduced glutathione (GSH); activities of glutathione peroxidase, catalase, and superoxide dismutase; and kidney function markers were measured. AOPP, TAC, and TBARS were significantly decreased, whereas GSH was significantly increased after KT. Antioxidant enzyme activities were not significantly changed during the monitored period after KT. Apropos specific kidney function markers and glomerular filtration significantly increased and creatinine level significantly decreased after transplantation. Changes in high-density lipoprotein cholesterol were also found. Our results show that successful KT results in normalization of the antioxidant status and lipid metabolism that is connected with both improved renal function and reduced cardiovascular complications.
Databáze:	OpenAIRE
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