CT-guided radiofrequency ablation after with transarterial chemoembolization in treating unresectable hepatocellular carcinoma with long overall survival improvement
| Autor: | Yong Jiang, Jian Peng Wang, Chang Chuan Pan, Pei Hong Wu, Wang Li, Wei Jun Fang, Liang Zhang, Ming Zhao, Xi Shan Li, Zi Lin Huang |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty China Carcinoma Hepatocellular Adolescent Radiofrequency ablation Computed tomography Ajcc stage law.invention Young Adult law medicine Overall survival Prevalence Hepatectomy Humans Radiology Nuclear Medicine and imaging Stage (cooking) Aged Univariate analysis medicine.diagnostic_test business.industry General surgery Liver Neoplasms General Medicine Middle Aged medicine.disease Institutional review board Combined Modality Therapy Embolization Therapeutic Survival Analysis Survival Rate Treatment Outcome Hepatocellular carcinoma Catheter Ablation Female Radiology business Tomography X-Ray Computed |
| Zdroj: | European journal of radiology. 81(10) |
| ISSN: | 1872-7727 |
| Popis: | To assess the time to disease progression (TTP), long-term survival benefit and safety of patients with unresectable hepatocellular carcinoma (HCC) treated with computed tomography (CT)-guided radiofrequency ablation (RFA) with transarterial chemoembolization chemoembolization (TACE).This study was approved by the institutional review board. We reviewed the records of patients with intermediate and advanced HCC treated with CT-guided RFA with TACE between January 2000 and December 2009. Median TTP, overall survival (OS) and hepatic function were analyzed with the Kaplan-Meier method and log-rank tests.One hundred and twenty-two patients (112 men and 10 women, mean age 53 years, range 18-86 years) were included in the study. The median follow-up time was 42 months (range 6-89 months), TTP was 6.8 months, the median OS was 31 months, and the 1-, 3-, and 5-year OS were 88.5%, 41.0%, and 10.7%. The results of the univariate analysis revealed that intrahepatic lesion, AJCC stage, and Child-Pugh stage were predictors of OS (P0.01). In the multivariate analysis, the AJCC stage system showed a statistically significant difference for prognosis. Procedure-related death was 0.21% (1/470) within 1 month, and a statistical difference was found between the TACE and RFA of liver decompensation and Child-Pugh stage (P0.05).The survival probabilities of OS increased with CT-guided RFA with TACE, as observed in randomized studies from Europe and Asia. The longest TTP was observed for the intermediate stage HCC. The procedures were well tolerated with acceptable minor and major complications in unresectable HCC patients. |
| Databáze: | OpenAIRE |
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