Customizing Perimetric Locations Based on En Face Images of Retinal Nerve Fiber Bundles With Glaucomatous Damage
| Autor: | Muhammed S. Alluwimi, Victor E. Malinovsky, Brett J King, William H. Swanson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
genetic structures Biomedical Engineering Nerve fiber layer Glaucoma Nerve fiber 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine perimetry Optical coherence tomography Ophthalmology medicine In patient optical coherence tomography medicine.diagnostic_test business.industry retinal nerve fiber bundles Retinal Articles medicine.disease eye diseases Ganglion glaucoma medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose Prior studies suggested the use of customized perimetric locations in glaucoma; these studies were limited by imaging only the superficial depths of the retinal nerve fiber layer (RNFL) and by prolonged perimetric testing. We aimed to develop a rapid perimetric test guided by high-resolution images of RNFL bundles. Methods We recruited 10 patients with glaucoma, ages 56 to 80 years, median 68 years, and 10 controls, ages 55 to 77 years, median 68 years. The patients were selected based on discrepancies between locations of glaucomatous damage for perimetric and structural measures. Montaging was used to produce optical coherence tomography en face images of the RNFL covering much of the 24-2 grid locations. In experiment 1, we presented the Goldmann size III stimulus at preselected retinal locations of glaucomatous damage, using just two contrasts. In experiment 2, we developed an elongated sinusoidal stimulus, aligned within the defect, to measure contrast sensitivities; abnormalities were defined based on lower 95% reference limits derived from the controls. Results The percentage of predicted locations where size III was not seen at 28 dB ranged from 16% to 80%, with a median of 48%. Contrast sensitivity for the sinusoidal stimulus was below the 95% reference range for 37 of 44 stimuli aligned within the defects. Conclusions We developed methods for rapid perimetric testing guided by en face images of the RNFL bundles in patients with glaucoma. Results indicated ganglion cell damage under all of the visible RNFL defects. Translational Relevance Customized perimetric locations have potential to improve clinical assessment of glaucoma. |
| Databáze: | OpenAIRE |
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