Synthesis, in Vitro Antimycobacterial and Antibacterial Evaluation of IMB-070593 Derivatives Containing a Substituted Benzyloxime Moiety

Autor:	Huiyuan Guo, Lan-Ying Sun, Jian Wang, Su-Jie Li, Bin Wang, Zengquan Wei, Yu Lu, Mingliang Liu
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Methicillin-Resistant Staphylococcus aureus Ofloxacin Staphylococcus aureus Magnetic Resonance Spectroscopy synthesis medicine.drug_class Stereochemistry Pharmaceutical Science benzyloxime Levofloxacin Microbial Sensitivity Tests Antimycobacterial Article Analytical Chemistry lcsh:QD241-441 Piperidines antibacterial activity lcsh:Organic chemistry Ciprofloxacin Drug Discovery Gram-Negative Bacteria Oximes medicine Moiety Physical and Theoretical Chemistry antimycobacterial activity Chemistry Organic Chemistry Mycobacterium tuberculosis In vitro Anti-Bacterial Agents Chemistry (miscellaneous) Lipophilicity Molecular Medicine Antibacterial activity IMB-070593 derivatives medicine.drug
Zdroj:	Molecules, Vol 18, Iss 4, Pp 3872-3893 (2013) Molecules Volume 18 Issue 4 Pages: 3872-3893
ISSN:	1420-3049
Popis:	A series of novel IMB-070593 derivatives containing a substituted benzyloxime moiety and displaying a remarkable improvement in lipophilicity were synthesized and evaluated for their in vitro antimycobacterial and antibacterial activity. Our results reveal that the target compounds 19a–m have considerable Gram-positive activity (MIC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3bbbb8d233ebac7106432e5aa0a1b2 http://www.mdpi.com/1420-3049/18/4/3872 Zobrazit plný text záznamu Plný text ve formátu PDF