Metabolic Outcomes in Adults Born Preterm With Very Low Birthweight or Small for Gestational Age at Term: A Cohort Study

Autor: Kari Anne I. Evensen, Chandima Nirupa Dilruks Balasuriya, Unni Syversen, Astrid Kamilla Stunes, Berit Schei, Mats Peder Mosti, Ingrid Hals, Marit S. Indredavik
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Waist
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Context (language use)
Blood Pressure
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Sex Factors
Bone Density
Pregnancy
Internal medicine
Medicine
Humans
Infant
Very Low Birth Weight
030212 general & internal medicine
Risk factor
reproductive and urinary physiology
Metabolic Syndrome
business.industry
Obstetrics
Biochemistry (medical)
Infant
Newborn
medicine.disease
chemistry
Prenatal Exposure Delayed Effects
Cancellous Bone
Infant
Small for Gestational Age
Homeostatic model assessment
Small for gestational age
Female
Glycated hemoglobin
Metabolic syndrome
Waist Circumference
business
Infant
Premature
Cohort study
Follow-Up Studies
Zdroj: The Journal of clinical endocrinology and metabolism. 103(12)
ISSN: 1945-7197
Popis: Low birthweight (LBW) has emerged as a risk factor of metabolic syndrome (MetS). Whether adults with very low birthweight (VLBW) born preterm are at higher risk than individuals who were term-born small for gestational age (tb-SGA) is not established. We assessed metabolic outcomes, including relation with skeletal parameters, in these two LBW categories.This follow-up cohort study included 189 individuals (females 51%), aged 25 to 28 years; 55 were preterm VLBW (≤1500 g), 59 were tb-SGA (10th percentile), and 75 were controls (≥10th percentile). Outcomes were indices of MetS: blood pressure (BP), waist circumference, fasting glucose, lipid profile, and association between calculated MetS score and bone mineral density (BMD) and trabecular bone score (TBS), a measure of bone quality.Compared with controls, individuals with VLBW displayed higher systolic [mean (SD), 126 (13.3) vs 119 (12.3) mm Hg; 95% CI, 1.27 to 11.48 mm Hg] and diastolic [71.9 (7.6) vs 68.6 (7.1) mm Hg; 95% CI, 0.3 to 6.2 mm Hg] BP, higher glycated hemoglobin, higher C-peptide, increased insulin resistance (Homeostatic Model Assessment 2), and lower high-density lipoprotein cholesterol [1.34 (0.3) vs 1.50 (0.4); 95% CI, 0.32 to 0.01]. Substantial differences were mainly seen between control females and females with VLBW. The adults who were tb-SGA had higher waist circumference and higher total and low-density lipoprotein cholesterol compared with controls. In males, MetS score correlated positively with BMD and inversely with TBS.The LBW groups and preferentially females in the VLBW group displayed a less favorable metabolic profile than did controls. The inverse association between MetS score and bone quality suggests enhanced future fracture risk.
Databáze: OpenAIRE
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