Effects of thyroid status on clonidine-induced hypo-activity responses in the developing rat
| Autor: | C. K. Atterwill, D.J. Heal, S. D. L. Smith |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Thyroid Hormones endocrine system medicine.medical_specialty endocrine system diseases Adrenergic receptor Ontogeny Adrenergic Alpha (ethology) Motor Activity Hyperthyroidism Clonidine Sex Factors Hypothyroidism Internal medicine medicine Animals Biological Psychiatry Thyroid Receptors Adrenergic alpha Rats Psychiatry and Mental health Endocrinology medicine.anatomical_structure Animals Newborn Neurology Female Alpha-2 adrenergic receptor Neurology (clinical) Hypoactivity Psychology medicine.drug |
| Zdroj: | Journal of Neural Transmission. 60:295-302 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/bf01249101 |
| Popis: | Clonidine-induced hypoactivity was studied in rats made neonatally hypo- and hyperthyroid (PTU or T4 administered between 1-27 days postnatally) as an indication of central presynaptic alpha 2-adrenoceptor function. Paradoxically, at 28 days postnatally both treatments caused an increase in clonidine-hypoactivity compared with untreated control animals, which was not due to sex differences amongst littermates in the various groups. It is proposed that whereas the hyperthyroid neonate data perhaps reflect an enhancement of presynaptic alpha 2 function similar to that seen in the adult rat brain, the result obtained for the hypothyroid neonates could perhaps be due to a retardation of the ontogeny of central noradrenergic neurones. |
| Databáze: | OpenAIRE |
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