Association of Plasma Transferrin With Cognitive Decline in Patients With Mild Cognitive Impairment and Alzheimer’s Disease
| Autor: | Guanan Zhao, Jingjing Guan, Peng Wang, Liping Lu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Longitudinal study medicine.medical_specialty Clinical Dementia Rating Cognitive Neuroscience lcsh:RC321-571 03 medical and health sciences iron mild cognitive impairment 0302 clinical medicine Neuroimaging Internal medicine mental disorders medicine transferrin Effects of sleep deprivation on cognitive performance Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research chemistry.chemical_classification business.industry longitudinal study Cognition 030104 developmental biology chemistry Transferrin Cohort business Alzheimer’s disease 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 12 (2020) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2020.00038 |
| Popis: | Objective: The objective of this study was to examine whether plasma transferrin levels are associated with longitudinal changes in cognitive performance in older individuals with normal cognition (CN), mild cognitive impairment (MCI), and mild Alzheimer’s disease (AD). Methods: At baseline, there were a total of 358 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort, including 58 older individuals with CN, 198 older individuals with MCI, and 102 patients with AD. Linear mixed models were utilized to examine the associations of plasma transferrin levels with changes in cognitive performance over time after adjustment of several potential covariates. The Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) were used to examine the global cognition of participants. Results: First, no significant differences in the plasma transferrin levels were observed across three diagnostic groups. Second, in the cross-sectional analyses, the baseline plasma transferrin levels were negatively associated with the MMSE scores in the CN group, but not in the MCI or the AD group. Third, in the longitudinal analyses, we found that a higher plasma transferrin was associated with a steeper cognitive decline in the MCI and AD groups, but not in the CN group. Conclusion: Higher plasma transferrin levels were associated with a steeper cognitive decline in participants with MCI and AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|