Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats
| Autor: | M.W. Owonikoko, B.O. Emikpe, Samuel Babafemi Olaleye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pulmonary toxicity Health Toxicology and Mutagenesis chemistry.chemical_element Physiology Histopathology 010501 environmental sciences Calcium Toxicology 01 natural sciences 03 medical and health sciences 0302 clinical medicine RA1190-1270 medicine ComputingMethodologies_COMPUTERGRAPHICS 0105 earth and related environmental sciences Cement dust Cement Cadmium Pneumoconiosis Regular Article medicine.disease Bioaccumulation chemistry Heavy metals Toxicity Toxicology. Poisons 030217 neurology & neurosurgery Exposure chamber |
| Zdroj: | Toxicology Reports, Vol 8, Iss, Pp 1169-1178 (2021) Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Exposure model is a reliable method of studying pulmonary toxicity of aerosolized xenobiotics. • Deposition of particles beyond the conducting zone and tissue bioaccumulation accompany exposure to cement dust (ECD). • Histoarchitectural alteration, body-organ weight discordance are indicators of acute ECD. A controlled experimental model of exposure to aerosols particularly for cement dust was recently invented in a study from the laboratory that found high serum levels of heavy metals, decrease gastrointestinal motility, and altered hematological variables in cement dust exposed rats. However, reproducibility was not considered. This work aims at standardizing the model and investigating preliminary toxicological indicators. Thirty male rats used in this study were divided into 3 groups (n = 10). Group 1; control, while groups 2 and 3 were exposed to cement dust for 14 days and 28 days respectively. We assessed clinical signs of toxicity, tissue heavy metal concentration, histopathological, and body weight (BW) changes. We observed poor movement coordination, abnormal posture, cephalic fur loss. Evidence of ischemia and fibrotic pneumoconiosis were grossly observed in the lungs of the exposed groups. There was a significant increase in tissue level of heavy metals with pulmonary and gastric heavy metal content showing a trendy relationship during the period of the exposure as the value of Lead, Chromium, Cadmium, Iron, Calcium, and Nickel increased by nearly similar percentages in both tissues. Organs weights increased; the 14-day exposed (198 ± 31; 168 ± 22) and 28-day exposed (198 ± 22; 187 ± 26) groups had significantly reduced body weight at the first and second weeks of exposure compared to the control group (265 ± 26; 357 ± 40) respectively. Exposure to cement dust induced low bone density in the exposed rats (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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